Liquisolid compacts of ketoprofen patch

Curcumin 198, indomethacin 219, griseofulvin 205, loperamide 208, ketoprofen 220. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid that works by reducing substances in the body that cause pain and inflammation. Based on the detection, pharmacokinetic parameters including c max, t max, and auc 08h were determined for both the formulations. Ketoplast 20mg 7 transdermal patch ketoprofen drug information. Low aqueous solubility is one of the major reasons for the poor clinical efficacy of carvedilol in oral therapy. It was derived from propionic acid by the research arm of boots uk during the 1960s, a period. Although the solubility of ketoprofen was found to be higher in propylene glycol pg compared to tween 80 112. Liquisolid compact tablets or capsules can be obtained after lipid dispersions are. Development of a novel ketoprofen transdermal patch. Therefore, ketoprofen establishes a good candidate for testing the potential of rapidrelease liquisolid compacts. The drug to be delivered is applied in high dose to the inside of the patch, which is sealed on the skin for long period of time 23 29. Nsaids can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. The optimization of ketoprofen liquisolid compacts was carried out by taking into consideration the liquid load factor, amount of coating material and amount of magnesium oxide as formulation variables and the cumulative percentage drug releaset 100% in minutes and angle of repose. Ketoprofen is thought to have antibradykinin activity, as well as lysosomal membranestabilizing action.

Nonprescription ketoprofen is used to relieve minor aches and pain from headaches, menstrual periods, toothaches, the common cold, muscle aches, and backaches, and to reduce fever. The aim of the present investigation was to enhance the dissolution of poorly watersoluble drug ramipril bcs ii drug through liquisolid compact. Physical characteristics, pharmacological properties and clinical. Enhancement of ketoconazole dissolution rate by the liquisolid. Formulation and invitro evaluation of mouth dissolving. Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch. The following drug interactions were studied with ketoprofen doses of 200 mgday. The experimental runs or formulation design were based on boxbehnken designs using response surface methodology and utilized to evaluate the response variables.

The main metabolite of ketoprofen is the pharmacologically inactive glucuronide conjugate. Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan. To overcome this problem, liquisolid technique has gained immense popularity as a novel approach in the last decade. It was concluded that ketoprofen in the liquisolid system was in a molecular form and no crystallinity or interaction were observed between ketoprofen and excipients.

A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Twelve formulations of conventional tablets were prepared using liquisolid technique with nonvolatile solvent systems tween 80, propylene glycol and peg 400. The main active ingredient or salt in this drug is ketoprofen. Design and evaluation of matrix diffusion controlled transdermal patches of. Transdermal adhesive patches loaded with ketoprofen evaluated. Transdermal drug delivery systems open access journals. Comparison of single dose transdermal patches of diclofenac. Formulation and characterization of ketoprofen liquisolid compacts by box behnken. Javadzadeh y, mohammed r, solamaz a,ali n, evaluated the effects of different grades of microcrystalline cellulose on flowability, compressibility and dissolution. Jan 07, 2020 ketoprofen is contraindicated for the treatment of perioperative pain in the setting of cabg surgery. Development of liquisolid tablets of chlorpromazine using. Ketoprofen side effects, dosage, interactions drugs.

Ketoprofen gel woodland hills compounding pharmacy. The experimental runs or formulation design were based on box. The aim of the present investigation was to evaluate the potential of liquisolid compact technique to enhance the dissolution rates of carvedilol and thereby the bioavailability. Liquisolid compacts, phdependent solubility, boxbehnken design 1. Liquisols of ketoprofen were prepared using polyethylene glycol peg 400 as liquid vehicle, avicel ph 102 as carrier and aerosil 200 as coating material. Ketoprofen is metabolised by the liver and excreted by the kidneys and, as such, it is dialyzable. Formulation and characterization of ketoprofen liquisolid compacts by. Abstact liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing compressible powders by blending with selected powder excipents. Identification of the substancemixture and of the companyundertaking product name. Studies on the local tolerance have shown that ketoprofen is well tolerated. Ketoprofen topical patch 20% in the treatment of pain.

The present study deals with the dissolution enhancement of meloxicam by liquisolid technique. Formulation and evaluation of liquisolid compacts of ketoprofen using different dissolution enhancers and to study the effect of addition of various superdisintegrants on rate dissolution of ketoprofen. Solubility enhancement of nifedipine using liquisolid. Then a standard calibration curve was constructed using ms excel as shown in fig 1. Nifedipine as a long and shortacting 1,4dihydropyridine calcium channel blocker. Ketoprofen is in a class of medications called nsaids.

Loxoprofen application did not show any improvement in gait, while ketoprofen dramatically improved gait disturbance figure 2a. Ketopatch 30 mg ketoprofen patch price, usage, dosage. Liquid solid compact technology is a novel approach to enhance. It is a propionic acid derivative and is a nonsteroidal antiinflammatory agent nsaia with analgesic and antipyretic properties. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween80 as. It acts by inhibiting the bodys production of prostaglandin. Oruvail capsules ketoprofen is also wellabsorbed from this dosage form, although an observable increase in plasma levels does not occur until approximately 2 to 3 hours after taking the formulation. Liquisolid compacts demonstrated significantly higher drug release rates, in different dissolution media and volumes, compared to tablet prepared by the direct compression method10. The incidence of common adverse reactions above 1% was obtained from a population of 835 orudis ketoprofen treated patients in doubleblind trials lasting from 4 to 54 weeks and in 622 oruvailtreated 200 mgday patients in trials lasting from 4 to 16 weeks.

Formulation and estimation of rheological parameters of topical gels of ketoprofen. Ketoprofen is contraindicated for the treatment of perioperative pain in the setting of cabg surgery. Ketoprofen is a bcs class ii drug with poor aqueous solubility and limited its bioavailability. The possibility of increased interaction should be kept in mind when orudis ketoprofen doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs.

The ketoprofen concentrations in the dermis, subcutaneous tissue, and plasma were compared with the commercially available patch mohrus. Ketoprofen topical patch 20% in the treatment of pain associated with shoulder, elbow or knee tendonitis or bursitis. Ketoprofen, 100 mg, has been tried as a patch to directly deliver the compound to the site of injury. This medication is a nonsteroidal antiinflammatory drug nsaid. Transdermal patch or adhesive patch or skin patch used to deliver a controlled dose of a drug through the skin over a period of time.

Characterization of the prepared liquisolid compacts. The prepared liquisolid compacts were evaluated for their flow. The release rate of ketoprofen from the drugaerogel formulation is much faster than that of the corresponding crystalline drugs. Ketoprofen fda prescribing information, side effects and uses. Gel based liquisolid compact approach is an extreme case of viscosity enhancement that restricts the molecular motion of drug molecules, in which the movement. Liquisolid technique is used in delivery of lipophilic and poorly water soluble drugs through oral route.

A wide variety of ketoprofen plaster options are available to you, such as medicine grade, food grade. Transdermal patch is a very simple and painless method for providing postoperative analgesia. It is practically insoluble in water, but is freely soluble in alcohol and ether. Antipyretic effects may be due to action on the hypothalamus, resulting in an. Ketoprofen gel ketoprofen, ketoprofen gel products. In addition to this, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. Design development of liquisolid compacts of atorvastatin calcium. The target organs for chronic toxicity are the gastrointestinal tract, the kidney and, to a lesser degree the liver. Results and discussion effect of vehicle type on the release of ketoprofen at different ph the release of ketoprofen from formulas f1, f2, and f3, which are formulated using pg, tween80 and peg as a vehicle respectively is shown in figure 1. Jun 01, 2019 ketoprofen capsules usp should not be given to patients who have experienced asthma, urticaria, or allergictype reactions after taking aspirin or other nsaids. Ketoprofen has analgesic, antiinflammatory, and antipyretic properties, and it is an inhibitor of cyclooxygenase. Another 10 patients served as the control group and were not given any drug.

Each nsaid ketoprofen, diclofenac, or loxoprofen, in the form of a gel or patch, was topically applied to the skin around the hind kneejoint before carrageenan injection. Orudis capsules ketoprofen is rapidly and wellabsorbed, with peak plasma levels occurring within 0. A wide variety of ketoprofen plaster options are available to you, such as grade standard. See what others have said about ketoprofen, including the effectiveness, ease of use and side effects. Ketoprofen topical patch, 20% in the treatment of pain. Because the patch facilitates delivery of ketoprofen over a 24hour period, the drug remains continually present in the tissue adjacent to the site of application.

Introduction carvedilol crv is an antihypertensive. The required quantities of ingredients for the compressible admixture were calculated using various mathematical models. It involves dissolving water insoluble drugs in nonvolatile. Liquisolid compacts are reported to be beneficial in enhancing, solubility 4, dissolution rate 5 and bioavailability 6 of poorly aqueous soluble drugs due to enhanced wetting properties.

The dissolution behavior of loratadine from liquisolid compacts was. The xrd patterns of ketoprofen raw material and solid dispersion 1. Development of a novel ketoprofen transdermal patch 228 pak. Currents were studied using the wholecell configuration of the patch clamp technique.

Aug 17, 2006 a phase iii study of the efficacy, tolerability and safety of the ketoprofen topical patch, 20% ktp in the treatment of pain associated with osteoarthritis flare of the knee, including a randomized, doubleblind, placebocontrolled, parallel group phase followed by an openlabel treatment phase. The objective of the present investigation was to formulate and evaluate the mouth dissolving tablets mdts of ketoprofen kpn using disintegrants like crospovidone cp, croscarmellose sodium ccs and sodium starch glycolate ssg and the effect of disintegrants on drug release was also studied. Ketoprofen transdermal patches in various doses have been found to be more effective than placebo in both traumatic and non traumatic pain without any additional side effects. This page also describes possible side effects and general precautions.

According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles, can be. This medicine may be used to treat osteoarthritis and rheumatoid arthritis, or painful monthly periods. Pharmaceutical dispersion techniques for dissolution and. Nsaids can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and. Currents were studied using the wholecell configuration of the patchclamp technique. It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. Side effects of orudis ketoprofen, warnings, uses rxlist. Ketoprofen is one of the propionic acid class of nonsteroidal antiinflammatory drugs nsaid with analgesic and antipyretic effects. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid. Drug ketoplast 20mg 7 transdermal patch ketoprofen. Liquisolid technique is a new and promising method that can change the dissolution rate of drugs.

Liquisolid compacts liquisols are the solid dosage forms with. Gel liquisolid compacts gls1gls10 and directly compressible tablets dct 1 and dct 2 of atorvastatin calcium were prepared and evaluated for flow properties, post compression parameters and in vitro dissolution studies. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. It suffers a low absolute bioavailability in humans approximately 30%. Formulation development of atorvastatin calciumtablets by.

Physicochemical and micromeritics properties of ketoprofentartaric. It acts by inhibiting the bodys production of prostaglandin it was patented in 1967 and approved for medical use in 1980. Apply 24 times a day for up to 7 days, ketoprofen 2. The objective of the present work was to obtain ph independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. There are 20 suppliers who sells ketoprofen plaster on, mainly located in asia. The antiinflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase2 cox2, an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. It was patented in 1967 and approved for medical use in 1980.

Formulation and characterization of ketoprofen liquisolid compacts by boxbehnken. Various forms of kp are available in the pharmaceutical market. Formulation and evaluation of ketoprofen by liquisolid. Nov 09, 2018 ketoprofen is a nonsteroidal antiinflammatory drug nsaid. Formulation and characterization of ketoprofen liquisolid compacts. Formulation and characterization of ketoprofen liquisolid. Vittal gv, deveswaran r, bharath s, basavaraj b, madhavan v. As this emedtv page explains, ketoprofen is a drug used to treat pain, inflammation, and swelling caused by several conditions. The dissolution profile and hardness of liquisolid compacts were not significantly. Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100mg administered via a patch is no more than 10% of that reported for ketoprofen 100mg administered orally. In the topical group, two patches were applied to the skin of the thigh over the semitendinosus muscle fig. Formulation development of atorvastatin calcium tablets by. Improvement of oral bioavailability of carvedilol by. Formulation and evaluation of transdermal patches of.

Ketoprofen is only found in individuals that have used or taken this drug. Materials and methods determination of solubility solubility studies of ketoprofen were carried out in water, phosphate buffer 7. Liquisolid compacts were prepared using transcutol hp as vehicle, avicel ph102 as carrier, and. Flurbiprofen is a member of the phenylalkanoic acid derivative family of nonsteroidal antiinflammatory drugs nsaids. Formulation and stability study of chlorpheniramine maleate. The low bioavailability of crv is attributed to its lower solubility and extensive hepatic metabolism 3,4. Different liquisolid compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptable and free flowing compressible mixtures. Both natural and synthetic polymers are used for the preparation of mucoadhesive buccal patches. It is used to reduce swelling and to treat mild to moderate pain. Ketoprofen capsules are contraindicated in the setting of coronary artery bypass graft.

Preparation and in vitro evaluation of ketoprofen solid. Avicel ph 102, aerosil200 were employed as carrier and coating materials. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. Experimental design of ketoprofen liquisolid compacts. The ketoprofen patches used in this study measured 7. Ketoprofen absorption by muscle and tendon after topical. Jul 14, 2006 ketoprofen topical patch 20% in the treatment of pain associated with shoulder, elbow or knee tendonitis or bursitis the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. In the present study, liquid solid technique is used to enhance the bioavailability of ketoprofen.

Pharmacokinetic data indicate that plasma levels of ketoprofen with oral. Structural analysis of gls was done using differential scanning calorimetry dsc and x ray powder diffraction xrd. When applied topically it reduces pain receptor sensitivity. It also reduces pain, swelling, and joint stiffness from arthritis. Topical application of ketoprofen improves gait disturbance. The limited solubility of drugs has always been a challenging task for pharmaceutical industries engaged in manufacturing and development of solid dosage forms.

Moreover, the topical ketoprofen patch was well tolerated. Formulation and characterization of ketoprofen liquisolid compacts by boxbehnken design. It is primarily indicated as a preoperative antimiotic in an ophthalmic solution as well as orally for arthritis or dental pain. Due to low systemic passage of ketoprofen from the gel such safety data are not relevant for local administration. Full text ketoprofenloaded polymer carriers in bigel formulation. Drug ketopatch 30mg 1 transdermal patch ketoprofen. The ratio which showed the best release was considered as the optimized formulation. Rjpdft research journal of pharmaceutical dosage forms and. Formulation and evaluation of transdermal patch of aceclofenac.

Identification of the substancemixture and of the companyundertaking. Indomethacin 219, griseofulvin 205, loperamide 208, ketoprofen 220. Preparation and characterization of liquisolid compacts. Our compounded gels and creams are used to help with mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. Liquisolid compacts were prepared using polyethylene glycol 400, neusilin us2 and aerosil 200. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween80 as liquid vehicles, hpmc as additives to increase loading capacity. Pdf investigating the use of liquisolid compacts technique to.

Brian birmingham, asokumar buvanendran, in practical management of pain fifth edition, 2014. Ketoprofen gel produces plasma levels that are about 60% lower than those experienced after a single oral dose of ketoprofen. Ketoprofen is used to relieve pain from various conditions. Severe, rarely fatal, anaphylactic reactions to ketoprofen have been reported in such patients. The aim of the study was to compare the efficacy and safety of transdermal patch of ketoprofen in comparison to diclofenac patch for postoperative analgesia. Find patient medical information for ketoprofen bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ketoprofen is a nonspecific cyclooxygenase inhibitor and inhibition of cox1 is thought to confer some of its side effects, such as gi upset and ulceration. The top countries of suppliers are china, south korea, from which the percentage of ketoprofen plaster supply is 90%, 10% respectively. List of drug master files dmf of ketoprofen active pharmaceutical ingredient api submitted to the u. Furthermore, naproxen liquisolid tablets were prepared using polyethylene glycol 400 peg400 and microcrystalline cellulose avicel ph 101, silica gel and 5% sodium starch glycolate. Ketoprofen api dmfs us drug master file dmf details. Ketoprofen works by reducing hormones that cause inflammation and pain in the body.